ANTIBACTERIAL INJECTABLE PHARMACEUTICAL COMPOSITION
The invention relates to the field of veterinary science and medicine and can be used for the prophylaxis and treatment of bacterial infections. The aim of the present invention is to design a preparation based on azithromycin in the form of a solution, having a wide spectrum of antimicrobial activi...
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Zusammenfassung: | The invention relates to the field of veterinary science and medicine and can be used for the prophylaxis and treatment of bacterial infections. The aim of the present invention is to design a preparation based on azithromycin in the form of a solution, having a wide spectrum of antimicrobial activity, and in the form of an injection solution ready for use not only for introduction intravenously, but also for intramuscular, subcutaneous, intrauterine and intracisternal introduction. The antibacterial pharmaceutical composition comprises azithromycin, a pH adjuster, solvents and/or cosolvents, a preservative, and an antioxidant. The antioxidant is in the form of thioglycerol, sodium ascorbate, 4-methyl-2,6-di-tert-butylphenol, 2,4,5-trihydroxybutyrophenone, and combination thereof, whereas the preservative is in the form of chloroethon or benzyl alcohol with the following ratios of components by percentage mass: 5-30% azithromycin, up to 5% pH adjuster, 0.5-1% preservative, 0.1-0.2% antioxidant, the remainder being solvents. |
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