INCREASED ETHANOL PRODUCTION BY THERMOPHILIC MICROORGANISMS WITH DELETION OF INDIVIDUAL HFS HYDROGENASE SUBUNITS

Disclosed are methods for engineering bacteria, for example, Thermoanaerobacterium saccharolyticum, that convert biomass to ethanol at high yield by deleting a single gene. Deletion of subunit A or subunit B of the hfs hydrogenase, but not deletion of subunit C or subunit D, results in an increase i...

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Bibliographische Detailangaben
Hauptverfasser: Lynd Lee R, Olson Daniel G, Eminoglu Aysenur
Format: Patent
Sprache:eng
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Zusammenfassung:Disclosed are methods for engineering bacteria, for example, Thermoanaerobacterium saccharolyticum, that convert biomass to ethanol at high yield by deleting a single gene. Deletion of subunit A or subunit B of the hfs hydrogenase, but not deletion of subunit C or subunit D, results in an increase in ethanol yield.