TRICYCLIC SULFONES AS ROR GAMMA MODULATORS

TRICYCLIC SULFONES AS ROR GAMMA MODULATORS

or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates, or prodrugs thereof, wherein all substituents are defined herein. Also provided are pharmaceutical compositions comprising the same. Such compounds and compositions are useful in methods for modulating RORγ activity in a cell...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Dhar T.G. Murali, Batt Douglas G, Weigelt Carolyn A, Duan Jingwu, Srivastava Anurag S, Shi Qing, Beaudoin Bertrand Myra, Liu Qingjie, Cornelius Lyndon A.M, Marcoux David, Cherney Robert J
Format: Patent
Sprache:eng
Schlagworte:
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates, or prodrugs thereof, wherein all substituents are defined herein. Also provided are pharmaceutical compositions comprising the same. Such compounds and compositions are useful in methods for modulating RORγ activity in a cell and methods for treating a subject suffering from a disease or disorder in which the subject would therapeutically benefit from modulation of RORγ activity, for example, autoimmune and/or inflammatory disorders.