SALTS OF PRODRUGS OF PIPERAZINE AND SUBSTITUTED PIPERIDINE ANTIVIRAL AGENTS

SALTS OF PRODRUGS OF PIPERAZINE AND SUBSTITUTED PIPERIDINE ANTIVIRAL AGENTS

This invention provides for prodrug Compounds I, pharmaceutical compositions thereof, and their use in treating HIV infection.wherein:X is C or N with the proviso that when X is N, R1 does not exist;W is C or N with the proviso that when W is N, R2 does not exist;V is C;E is hydrogen or a pharmaceut...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: UEDA Yasutsugu, YEUNG Kap-Sun, LEAHY David Kenneth, LEVESQUE Kathia, ZHANG Zhongxing, WANG Tao, KADOW John F, SOUNDARARAJAN Nachimuthu, THORAVAL Dominique, MEANWELL Nicholas A, CONNOLLY Timothy P, PACK Shawn K, SIRARD Pierre, CHEN Chung-Pin H
Format: Patent
Sprache:eng
Schlagworte:
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:This invention provides for prodrug Compounds I, pharmaceutical compositions thereof, and their use in treating HIV infection.wherein:X is C or N with the proviso that when X is N, R1 does not exist;W is C or N with the proviso that when W is N, R2 does not exist;V is C;E is hydrogen or a pharmaceutically acceptable salt thereof; andY is selected from the group consisting ofAlso, this invention provides for intermediate Compounds II useful in making prodrug Compounds I.wherein:L and M are independently selected from the group consisting of C1-C6 alkyl, phenyl, benzyl, trialkylsilyl, -2,2,2-trichloroethoxy and 2-trimethylsilylethoxy.