NOVEL TRICYCLIC COMPOUNDS AS INHIBITORS OF MUTANT IDH ENZYMES

The present invention is directed to tricyclic compounds of formula (I) which are inhibitors of one or more mutant IDH enzymes (I); wherein A is -C(R1)= or -N=; and X is selected from the group consisting of: (II-i), and (II-ii). The present invention is also directed to uses of the tricyclic compou...

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Hauptverfasser:	Kattar Solomon D, Ellis Michael J, Reutershan Michael H, Ujjainwalla Feroze, Fradera Llinas Francesc Xavier, Hoffman Dawn M, Shao Patrick Pengcheng, Fischer Christian, Childers Matthew L, Parker, Jr. Dann L, Wu Zhicai, Yu Yang, Esposite Sara, Sciammetta Nunzio, Sloman David L, Machacek Michelle R, McMasters Daniel R, Huang Chunhui, Sun Wanying, Lampe John W, Kim Alexander J, Bogen Stephane L, Gibeau Craig R
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY
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