NOVEL TRICYCLIC COMPOUNDS AS INHIBITORS OF MUTANT IDH ENZYMES

NOVEL TRICYCLIC COMPOUNDS AS INHIBITORS OF MUTANT IDH ENZYMES

The present invention is directed to tricyclic compounds of formula (I) which are inhibitors of one or more mutant IDH enzymes (I); wherein A is -C(R1)= or -N=; and X is selected from the group consisting of: (II-i), and (II-ii). The present invention is also directed to uses of the tricyclic compou...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Kattar Solomon D, Ellis Michael J, Reutershan Michael H, Ujjainwalla Feroze, Fradera Llinas Francesc Xavier, Hoffman Dawn M, Shao Patrick Pengcheng, Fischer Christian, Childers Matthew L, Parker, Jr. Dann L, Wu Zhicai, Yu Yang, Esposite Sara, Sciammetta Nunzio, Sloman David L, Machacek Michelle R, McMasters Daniel R, Huang Chunhui, Sun Wanying, Lampe John W, Kim Alexander J, Bogen Stephane L, Gibeau Craig R
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The present invention is directed to tricyclic compounds of formula (I) which are inhibitors of one or more mutant IDH enzymes (I); wherein A is -C(R1)= or -N=; and X is selected from the group consisting of: (II-i), and (II-ii). The present invention is also directed to uses of the tricyclic compounds described herein in the potential treatment or prevention of cancers in which one or more mutant IDH enzymes are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such cancers.