Optimizing Total Energy Delivered in Nanosecond Pulses for Triggering Apoptosis in Cultured Cells

Optimizing Total Energy Delivered in Nanosecond Pulses for Triggering Apoptosis in Cultured Cells

An optimization of electrical characteristics for treatments of tumor or other abnormal cells in culture with sub-microsecond, high-electric field electrical pulses is disclosed. The voltages, pulse widths, and number of pulses are chosen such that the treatment energy is 10-20 J/mL. That is, U=n*Δt...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Mallon Zachary R, Kreis Mark P, Danitz David J, Uecker Darrin R, Nuccitelli Richard L, McDaniel Amanda H, Athos Brian G, Nuccitelli Pamela S
Format: Patent
Sprache:eng
Schlagworte:
DIAGNOSIS
ELECTROTHERAPY
HUMAN NECESSITIES
HYGIENE
IDENTIFICATION
MAGNETOTHERAPY
MEDICAL OR VETERINARY SCIENCE
RADIATION THERAPY
SURGERY
ULTRASOUND THERAPY
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Beschreibung
Zusammenfassung:An optimization of electrical characteristics for treatments of tumor or other abnormal cells in culture with sub-microsecond, high-electric field electrical pulses is disclosed. The voltages, pulse widths, and number of pulses are chosen such that the treatment energy is 10-20 J/mL. That is, U=n*Δt*V*I/volume is 10-20 J/mL, in which n is the number of pulses, Δt is the duration of each pulse, V is the voltage, I is current, and volume is the area of parallel electrodes times the distance between them. V divided by the distance between the electrodes can be in an effective range of 6 kV/cm to 30 kV/cm, 60 kV/cm, 100 kV/cm, or higher intensities. Rows of needle electrodes, blade electrodes, or other configurations of electrodes can approximate parallel electrodes.