GENETIC TESTING FOR PREDICTING RESISTANCE OF KLEBSIELLA SPECIES AGAINST ANTIMICROBIAL AGENTS

The invention relates to a method of determining an infection of a patient with Klebsiella species potentially resistant to antimicrobial drug treatment by detecting mutations in the genes, parC, KPN 01607, gyrA, KPN 02451, baeR, aceF, ybgH, ynjE, KPN 01951, KPN 01961, KPN 02114, mhpA, KPN 02128, KP...

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Bibliographische Detailangaben
Hauptverfasser:	Schmolke Susanne, Stahler Cord Friedrich, Backes Christina, Keller Andreas
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTEDFOR SPECIFIC APPLICATION FIELDS MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PHYSICS PROCESSES OF PREPARING SUCH COMPOSITIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention relates to a method of determining an infection of a patient with Klebsiella species potentially resistant to antimicrobial drug treatment by detecting mutations in the genes, parC, KPN 01607, gyrA, KPN 02451, baeR, aceF, ybgH, ynjE, KPN 01951, KPN 01961, KPN 02114, mhpA, KPN 02128, KPN 02144, KPN 02149, ydiJ, btuE, oppC, pth, KPN 02298, KPN 02302, dadA, yoaA, ftn, cbl, hisB, yegQ, yehY, KPN 02580, yejH, KPN 02621, yfaW, KPN 02170, KPN 02025, livG, livM, livH, fliY, yedQ, abgB, treA, baeS, KPN 02399, ydcR, anmK, ccmF, KPN 02440, KPN 02540, KPN 01752, and KPN 04195, and/or KOX 26125, KOX 13365, KOX 16735, KOX 25695, KOX 12270, and KOX 15055; a method of selecting a treatment of a patient suffering from an antibiotic resistant Klebsiella infection; and a method of determining an antibiotic resistance profile for bacterial microorganisms of Klebsiella species, as well as computer program products used in these methods. In an exemplary method, a sample is used for molecular testing and then a molecular fingerprint is taken. The result is then compared to a reference library and the result is reported.