Partial Adaption for Butanol Production

Provided herein are processes for producing an improved culture of cells comprising an engineered butanol biosynthetic pathway. The processes comprise (a) providing a cell culture of recombinant microorganisms comprising an engineered butanol biosynthetic pathway, wherein the engineered butanol bios...

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Bibliographische Detailangaben
Hauptverfasser: KONDE KAKASAHEB SURESH, PATNAIK RANJAN, Bhalla Ritu, DOIG STEVEN D
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:Provided herein are processes for producing an improved culture of cells comprising an engineered butanol biosynthetic pathway. The processes comprise (a) providing a cell culture of recombinant microorganisms comprising an engineered butanol biosynthetic pathway, wherein the engineered butanol biosynthetic pathway is minimal or not activated; and (b) growing the culture of recombinant microorganisms under adaptive conditions whereby pathway activation is increased to produce an improved cell culture and whereby said improved cell culture is capable of continuing to grow in fermentation.