INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL

The present invention provides compounds of Formula I and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascul...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Jiang Jinlong, Ding Fa-Xiang, DeJesus Reynalda K, Tang Haifeng, Gu Xin, Frie Jessica, Pu Zhifa, Suzuki Takao, Pasternak Alexander, Dong Shuzhi, Fu Qinghong
Format: Patent
Sprache:eng
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Zusammenfassung:The present invention provides compounds of Formula I and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive salt and water retention.