CHEMICALLY-LOCKED BISPECIFIC ANTIBODIES

CHEMICALLY-LOCKED BISPECIFIC ANTIBODIES

There is disclosed a process for forming chemically-locked bispecific or heterodimer antibodies, preferably in the IgG class, in high specificity and with high homogeneity. More specifically, there is disclosed a chemically-locked bispecific IgG class antibody having a linkage region joined together...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Fu Yanwen, Toughiri Raheleh, Kaufmann Gunnar F, Jones Bryan
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Beschreibung
Zusammenfassung:There is disclosed a process for forming chemically-locked bispecific or heterodimer antibodies, preferably in the IgG class, in high specificity and with high homogeneity. More specifically, there is disclosed a chemically-locked bispecific IgG class antibody having a linkage region joined together with bio-orthogonal click chemistry.