TRIAZINE COMPOUNDS AS PI3 KINASE AND MTOR INHIBITORS

TRIAZINE COMPOUNDS AS PI3 KINASE AND MTOR INHIBITORS

and R2, R4, and R6-9 are defined herein, and pharmaceutically acceptable salts and esters thereof. These compounds inhibit PI3 kinase and mTOR, and may be used to treat diseases mediated by PI3 kinase and mTOR, such as a variety of cancers. Methods for making and using the compounds of this inventio...

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Bibliographische Detailangaben
Hauptverfasser: CHEN Zecheng, RICHARD David James, DEHNHARDT Christoph Martin, AYRAL-KALOUSTIAN Semiramis, DOS SANTOS Osvaldo, MANSOUR Tarek Suhayl, VENKATESAN Aranapakam Mudumbai, GOPALSAMY Ariamala, VERHEIJEN Jeroen Cunera, SHI Mengxiao, ZASK Arie, DELOS SANTOS Efren Guillermo, KAPLAN Joshua Aaron, CURRAN Kevin Joseph
Format: Patent
Sprache:eng
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:and R2, R4, and R6-9 are defined herein, and pharmaceutically acceptable salts and esters thereof. These compounds inhibit PI3 kinase and mTOR, and may be used to treat diseases mediated by PI3 kinase and mTOR, such as a variety of cancers. Methods for making and using the compounds of this invention are disclosed. Various compositions containing the compounds of this invention are also disclosed.