Modified Latency Associated Protein Construct

The present invention provides a fusion protein comprising a latency associated peptide (LAP), a pharmaceutically active agent and an amino acid sequence comprising a dimerisation domain, wherein the LAP and the pharmaceutically active agent are connected by an amino acid sequence comprising a prote...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Gould David James, Muhammad Hawzheen, Mullen Lisa, Adams Gillian, Chernajovsky Yuti
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:The present invention provides a fusion protein comprising a latency associated peptide (LAP), a pharmaceutically active agent and an amino acid sequence comprising a dimerisation domain, wherein the LAP and the pharmaceutically active agent are connected by an amino acid sequence comprising a proteolytic cleavage site. Also provided are nucleic acids enclosing such fusion proteins, process for their preparation, pharmaceutical compositions, kits and uses thereof in medicine.