PYRIDONE AND AZA-PYRIDONE COMPOUNDS AND METHODS OF USE

PYRIDONE AND AZA-PYRIDONE COMPOUNDS AND METHODS OF USE

Pyridone and aza-pyridone compounds of Formula I are provided, including stereoisomers, tautomers, and pharmaceutically acceptable salts thereof, useful for inhibiting Btk kinase, and for treating immune disorders such as inflammation mediated by Btk kinase. Methods of using compounds of Formula I f...

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Bibliographische Detailangaben
Hauptverfasser: BLOMGREN Peter A, SCHMITT Aaron C, WANG Xiaojing, ZHICHKIN Pavel E, MITCHELL Scott A, XU Jianjun, ZHANG Honglu, YOUNG Wendy, BARBOSA Antonio J.M, KRISHNAMOORTHY Ravi, ORTWINE Daniel, ZHAO Zhongdong, LEE Seung H, CURRIE Kevin S, KROPF Jeffrey E
Format: Patent
Sprache:eng
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:Pyridone and aza-pyridone compounds of Formula I are provided, including stereoisomers, tautomers, and pharmaceutically acceptable salts thereof, useful for inhibiting Btk kinase, and for treating immune disorders such as inflammation mediated by Btk kinase. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, and treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.