Imidazothiazole Derivatives as Modulators of TNF Activity

A series of substituted imidazo[2,1-b]thiazole derivatives, and analogues thereof, being potent modulators of human TNFα activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerat...

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Hauptverfasser: Jackson Victoria Elizabeth, Alexander Rikki Peter, Ali Mezher Hussein, Brown Julien Alistair
Format: Patent
Sprache:eng
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Zusammenfassung:A series of substituted imidazo[2,1-b]thiazole derivatives, and analogues thereof, being potent modulators of human TNFα activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.