Fused Tricyclic Imidazole Derivatives As Modulators of TNF Activity

Fused Tricyclic Imidazole Derivatives As Modulators of TNF Activity

A series of fused tricyclic imidazole derivatives, in particular dihydro-1H-cyclopenta[4,5]imidazo[1,2-a]pyridine derivatives, and analogues thereof, being potent modulators of human TNFα activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including aut...

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Hauptverfasser: BRACE Gareth Neil, GALLIMORE Ellen Olivia, KROEPLIEN Boris, HEINELT Uwe, WEHNER Volkmar, ALEXANDER Rikki Peter, SABNIS Yogesh Anil, JACKSON Victoria Elizabeth, ZHU Zhaoning, DELIGNY Michael, QUINCEY Joanna Rachel, MAC COSS Malcolm, BROWN Julien Alistair, SWINNEN Dominique Louis Léon, CALMIANO Mark Daniel, HEER Jag Paul, CHOVATIA Praful Tulshi
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:A series of fused tricyclic imidazole derivatives, in particular dihydro-1H-cyclopenta[4,5]imidazo[1,2-a]pyridine derivatives, and analogues thereof, being potent modulators of human TNFα activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.