MAGNETIC APPARATUS AND METHODS OF USE

Provided herein is a magnetic apparatus for collecting superparamagnetic particles from a subject. The superparamagnetic particles are previously injected into the subject and have ligands bound thereto that are specific for one or more non-cell biomarkers. In one embodiment, the superparamagnetic p...

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Bibliographische Detailangaben
Hauptverfasser:	Dobson Jon Paul, Yarmola Elena Georgina, Allen Kyle Douglas, Kaufman Zachary, Arnold David P
Format:	Patent
Sprache:	eng
Schlagworte:	DIAGNOSIS HUMAN NECESSITIES HYGIENE IDENTIFICATION INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE PHYSICS SURGERY TESTING
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Beschreibung
Zusammenfassung:	Provided herein is a magnetic apparatus for collecting superparamagnetic particles from a subject. The superparamagnetic particles are previously injected into the subject and have ligands bound thereto that are specific for one or more non-cell biomarkers. In one embodiment, the superparamagnetic particles are injected into and retrieved from a cavity such as a joint cavity. These compositions and methods allow for the sequestration and removal of inflammatory mediators, as both a diagnostic of the local immune response and a therapeutic that can reduce inflammation in the local disease environment.