METHOD AND APPARATUS TO CONCENTRATE AND DETECT AN ANALYTE IN A SAMPLE

Devices and methods for detecting the presence or absence and/or one or more characteristics of analytes are disclosed. Embodiments of the disclosed devices include an actuator having a staging reservoir which can be operably connected with an electrophoresis assembly. In some embodiments, the discl...

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Bibliographische Detailangaben
Hauptverfasser: Arenas Jaime E, Hu David, Hu Celine, Lyon Greg, Guo Bin
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:Devices and methods for detecting the presence or absence and/or one or more characteristics of analytes are disclosed. Embodiments of the disclosed devices include an actuator having a staging reservoir which can be operably connected with an electrophoresis assembly. In some embodiments, the disclosed methods include operating the subject devices, for example, by actuating the actuator to operably connect, e.g., fluidically connect, components of the devices, and electrophoresing or otherwise propelling a sample through portions of the devices. In some embodiments, the disclosed methods include detecting an analyte and/or analyzing properties of a sample, such as one or more characteristics of an analyte in a sample. The analyte of interest can be a charged molecule or can be modified to be charged using, for example, one or more ionic moieties.