OPTICAL ISOMERS OF (+) AND (-)-BENZHYDRYL UREAS AND (+) AND (-)-1-[(3-CHLOROPHENYL)-PHENYL-METHYL] UREA, A PHARMACEUTICAL COMPOSITION BASED THEREON AND A METHOD FOR PRODUCING SAID OPTICAL ISOMERS

OPTICAL ISOMERS OF (+) AND (-)-BENZHYDRYL UREAS AND (+) AND (-)-1-[(3-CHLOROPHENYL)-PHENYL-METHYL] UREA, A PHARMACEUTICAL COMPOSITION BASED THEREON AND A METHOD FOR PRODUCING SAID OPTICAL ISOMERS

The invention relates to novel substances, and more particularly to optical isomers of (+) and (−)-benzhydryl ureas of formula (I) and (+) and (−)-1-[(3-chlorophenyl)-phenyl-methyl]urea, a pharmaceutical composition based thereon, and a method for producing said optical isomers and for using same on...

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Bibliographische Detailangaben
Hauptverfasser: KUKSIONOK Vera Yurievna, HUDOLEY Vladimir Nikolaevich, SHTRYKOVA Viktoria Viktorovna, DOROSHENKO Aleksandr Sergeevich, FILIMONOV Vikto Dmitrievich
Format: Patent
Sprache:eng
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The invention relates to novel substances, and more particularly to optical isomers of (+) and (−)-benzhydryl ureas of formula (I) and (+) and (−)-1-[(3-chlorophenyl)-phenyl-methyl]urea, a pharmaceutical composition based thereon, and a method for producing said optical isomers and for using same on the basis of the different therapeutic activity exhibited. (I) Where R≠R′ and are selected from the group comprising hydrogen, alkyl, halogen, nitro, amino, alkylamino and hydroxy groups and are situated in the ortho-, para- or meta-positions of the benzene rings. When racemic Halodif 1-[(3-chlorophenyl)-phenyl-methyl]urea was separated using the method according to the invention, optical isomers of (+) and (−)-1-[(3-chlorophenyl)-phenyl-methyl]urea (Halodif isomers) with different degrees of therapeutic activity were produced.