COMPOUNDS FOR REGULATING FAK AND/OR SRC PATHWAYS

The present application provides novel optionally substituted fused pyridine and pyrimidine bicyclic compounds and pharmaceutically acceptable salts thereof. Also provided are methods for preparing these compounds. These compounds are useful in co-regulating FAK and/or Src activity by administering...

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Bibliographische Detailangaben
Hauptverfasser:	Tyagi Rajiv, Sivanandhan Dhanalakshmi, Smith Roger A, Hallur Gurulingappa, Pendyala Muralidhar, Venkatesan Aranapakam M, Thompson Scott K, Kethiri Raghava Reddy, Laping Nicholas, Kulkarni Bheemashankar, Viswanadhan Vellarkad N, Bakthavatchalam Rajagopal
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY ELECTROTHERAPY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MAGNETOTHERAPY MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES RADIATION THERAPY ULTRASOUND THERAPY
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Beschreibung
Zusammenfassung:	The present application provides novel optionally substituted fused pyridine and pyrimidine bicyclic compounds and pharmaceutically acceptable salts thereof. Also provided are methods for preparing these compounds. These compounds are useful in co-regulating FAK and/or Src activity by administering a therapeutically effective amount of one or more of the compounds to a subject. By doing so, these compounds are effective in treating conditions associated with the dysregulation of the FAK and/or Src pathway. Advantageously, these compounds perform as dual FAK and/or Src inhibitors. A variety of conditions can be treated using these compounds and include diseases which are characterized by inflammation or abnormal cellular proliferation. In one embodiment, the disease is cancer.