Biaryl Acyl-Sulfonamide Compounds as Sodium Channel Inhibitors

Biaryl Acyl-Sulfonamide Compounds as Sodium Channel Inhibitors

The present invention provides compounds of Formula (Ia), and pharmaceutically acceptable salts thereof. The compounds are useful as inhibitors of voltage-gated sodium channels, in particular Nav 1.7. as described in the specification. The compounds are useful for the treatment of diseases treatable...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: WEISS Matthew, BERGMAN Howard, GUNAYDIN Hakan, HUANG Homgbing, GAO Hau, CHAKKA Nagasree, SCHENKEL Laurie, OLIVIERI Philip R, DIMAURO Erin F
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The present invention provides compounds of Formula (Ia), and pharmaceutically acceptable salts thereof. The compounds are useful as inhibitors of voltage-gated sodium channels, in particular Nav 1.7. as described in the specification. The compounds are useful for the treatment of diseases treatable by inhibition of sodium channels such as pain disorders. Also provided are pharmaceutical compositions containing compounds of the present invention, as well as intermediates and processes useful for making the compounds.