Cyclosporine Analogue Molecules Modified At Amino Acid 1 and 3

Cyclosporine Analogue Molecules Modified At Amino Acid 1 and 3

Analogues of cyclosporin-A are disclosed comprising modifications of the substituents as the positions of amino acids 1 and 3, according to the following Formula. The disclosed compounds include compounds having affinity for cyclophilin, including cyclophilin-A, and reduced immunosuppressivity in co...

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Hauptverfasser: SUGIYAMA SHIN, TREPANIER DAN J, URE DAREN R, FENSKE BRUCE W, ABEL MARK D, HEGMANS ALEXANDER
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Beschreibung
Zusammenfassung:Analogues of cyclosporin-A are disclosed comprising modifications of the substituents as the positions of amino acids 1 and 3, according to the following Formula. The disclosed compounds include compounds having affinity for cyclophilin, including cyclophilin-A, and reduced immunosuppressivity in comparison with cyclosporin-A and analogs thereof modified solely at position 1.