PHARMACEUTICAL COMPOUNDS

Compounds of Formulae Ia, and stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting lipid kinases including PI3K, and for treating disorders such as cancer mediated by lipid kinases. Methods of using compounds of F...

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Bibliographische Detailangaben
Hauptverfasser:	SHUTTLEWORTH STEPHEN, ZHU BING-YAN, FOLKES ADRIAN, MATHIEU SIMON, OLIVERO ALAN, CHUCKOWREE IRINA, OXENFORD SALLY, GUNZER-TOSTE JANET, SUTHERLIN DANIEL P, WAN NAN CHI, HEFFRON TIM, GOLDSMITH RICHARD, CASTANEDO GEORGETTE
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	Compounds of Formulae Ia, and stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting lipid kinases including PI3K, and for treating disorders such as cancer mediated by lipid kinases. Methods of using compounds of Formula Ia for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.