Skin Treatments Containing Carboxylic Acid-Substituted Idebenone Derivatives and Methods of Preparation and Use Thereof

The present invention relates to novel carboxylic acid-substituted idebenone derivatives, skin treatment compositions containing these carboxylic acid-substituted derivatives, methods of treating skin changes by topical application of these carboxylic acid-substituted idebenone derivatives, and thei...

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Bibliographische Detailangaben
Hauptverfasser:	DINARDO JOESPEH C, THOMPSON ANDREW S, NEUDECKER BIRGIT, DIEDRICH FALKO, LEWIS, III JOSEPH A, WIELAND EBERHARD, KERSCHEN JAMES ALAN, WADE PETER C
Format:	Patent
Sprache:	eng
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC USE OF COSMETICS OR SIMILAR TOILETPREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to novel carboxylic acid-substituted idebenone derivatives, skin treatment compositions containing these carboxylic acid-substituted derivatives, methods of treating skin changes by topical application of these carboxylic acid-substituted idebenone derivatives, and their methods of synthesis. The carboxylic acid-substituted idebenone derivatives of the present invention are unexpectedly effective in treating skin, particularly with respect to skin tolerance. When included in a topical composition, the carboxylic acid-substituted idebenone derivatives of the present invention have an antioxidant effect that is useful in treating a skin change.