METHOD FOR PRODUCING BETA-HEMATIN CRYSTAL COMPRISING STEP OF HEATING

METHOD FOR PRODUCING BETA-HEMATIN CRYSTAL COMPRISING STEP OF HEATING

This invention provides a method of preparing a -hematin crystal comprising a step of heating, the -hematin crystal obtained by such method, and a vaccine adjuvant composition containing the -hematin crystal. The -hematin crystal has a needle-like morphology, it has an average particle size of 0.6 t...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: IGARI YOSHIKATSU, OTSUKI AKINA, COBAN CEVAYIR, KANO YASUMASA, ISHII KEN, AKIRA SHIZUO
Format: Patent
Sprache:eng
Schlagworte:
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:This invention provides a method of preparing a -hematin crystal comprising a step of heating, the -hematin crystal obtained by such method, and a vaccine adjuvant composition containing the -hematin crystal. The -hematin crystal has a needle-like morphology, it has an average particle size of 0.6 to 1.2 μm, and it exhibits main peaks characteristics for angles of diffraction (2 ) of 7.4°, 12.2°, 21.6°, and 24.1° in an X-ray diffraction pattern obtained by powder X-ray diffractometry with Cu-Kα rays (with each peak including a plus-minus 0.2° diffraction angle).