Anti-TNF-alpha/CXCL10 Double-Targeting Antibody and Use Thereof

The present invention relates to a TNF-α (tumor necrosis factor-alpha)/CXCL-10 (C-X-C motif chemokine 10) double targeting antibody based on the IgG format. Specifically, it was verified that an antibody, in which scFv having a heavy chain variable domain and a light chain variable domain of the CXC...

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Bibliographische Detailangaben
Hauptverfasser:	KIM DONG JIN, JANG MYEOUNG HEE, SONG YEONG WOOK, LEE DONG HEE, LEE EUN YOUNG, PARK BUMAN, JANG SEIL, KANG HEUN-SOO, YUN SEON HA, PARK SO-HYUN, SHIN KI CHUL, KIM KYUNG JIN, LEE KE SE, PARK YOUNG WOO, LEE HYUN JU, KIM HEE CHAN, YOO SEOK HO, LEE EUN BONG
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY METALLURGY ORGANIC CHEMISTRY PEPTIDES
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Beschreibung
Zusammenfassung:	The present invention relates to a TNF-α (tumor necrosis factor-alpha)/CXCL-10 (C-X-C motif chemokine 10) double targeting antibody based on the IgG format. Specifically, it was verified that an antibody, in which scFv having a heavy chain variable domain and a light chain variable domain of the CXCL10 specific antibody links to the C-terminus of the heavy chain constant domain of the TNF-α specific antibody, is a bispecific antibody that effectively binds to both TNF-α and CXCL10, and thus the antibody can be useful as a double targeting antibody capable of identifying TNF-α/CXCL10. A composition of the present invention comprises a TNF-α/CXCL-10 double targeting antibody which effectively binds to both TNF-α and CXCL10. The double targeting antibody of the present invention has excellent TNF-α inhibitory activity and osteoclast differentiation inhibitory activity compared with the TNF-α or CXCL10 single targeting antibody. The composition of the present invention can be used in preventing or treating immunological disease.