METHODS OF ACUTE RESTORATION OF VASCULAR COMPLIANCE

Disclosed herein is a compound for use in a composition applied to a blood vessel, wherein the compound softens and/or disrupts the crystalline matrix of calcified plaque, as well as acutely restoring the vascular compliance at the treatment site of the blood vessel, while maintaining luminal gain d...

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Bibliographische Detailangaben
Hauptverfasser: DOWNEY THERESE J, UTECHT RONALD E, HABERER BARBARA R
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:Disclosed herein is a compound for use in a composition applied to a blood vessel, wherein the compound softens and/or disrupts the crystalline matrix of calcified plaque, as well as acutely restoring the vascular compliance at the treatment site of the blood vessel, while maintaining luminal gain during angioplasty. Methods of treatment comprising applying the disclosed composition are also disclosed. Plaque-softening compounds are also disclosed.