Systems and Methods for Determining Patient Adherence to a Prescribed Medication Protocol

Systems and methods are provided for determining patient adherence to a medication protocol by evaluating healthcare transactions. An e-prescription transaction can be received from a prescriber and evaluated to determine if the patient is to receive adherence analysis. If so, the e-prescription data can be stored and the e-prescription can be forwarded to a pharmacy. A healthcare claim transaction for a medication can be received from the pharmacy and forwarded on for adjudication. If approved, the claim transaction data can be evaluated to determine if it matches any stored e-prescription data records. Upon identifying a match, a prescription fill status notification can be generated and transmitted to the prescriber computer associated with the prescriber of the medication in the e-prescription. If the healthcare claim transaction is for a refill or a maintenance medication, a patient adherence level can be calculated and included in the prescription fill status notification.