PEPTIDE INHIBITORS OF NICOTINIC ACETYLCHOLINE RECEPTOR

PEPTIDE INHIBITORS OF NICOTINIC ACETYLCHOLINE RECEPTOR

The present invention refers to biochemistry, namely to new peptide compounds having the ability to selectively block the muscle-type nicotinic acetylcholine receptor. The claimed compounds have common formula (I): X1-X2-X3-Pro-X4-Pro-X5 (SEQ ID NO: 54), where X1 is chosen within H, Ac-, Palm-; X2 i...

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Hauptverfasser: KRYUDOVA ELENA VIKTOROVNA, KASHEVEROV IGOR EVGEN'EVICH, KUDRYAVTSEV DENIS SERGEEVICH, STARKOV VLADLSLAV GENNAD'EVICH, ZHMAK MAXIM NURGAYANOVICH, SHELUKHINA IRINA VALER'EVNA, TSETLIN VIKTOR IONOVICH, ANDREEVA TATYANA VIKTOROVNA, UTKIN YURY NIKOLAEVICH
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC USE OF COSMETICS OR SIMILAR TOILETPREPARATIONS
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Beschreibung
Zusammenfassung:The present invention refers to biochemistry, namely to new peptide compounds having the ability to selectively block the muscle-type nicotinic acetylcholine receptor. The claimed compounds have common formula (I): X1-X2-X3-Pro-X4-Pro-X5 (SEQ ID NO: 54), where X1 is chosen within H, Ac-, Palm-; X2 is chosen within Trp, Tyr; X3 is chosen within Trp, Tyr; X4 is chosen within Lys, Orn, Dbu, Dpr, Arg; X5 is chosen within -OH, -NH2, -OCH3, -OC2H5, -NH-C6H5. The invention can be applied in cosmetics for smoothing mimic and age-related wrinkles