Processes for the Preparation of Chiral Beta Amino Acid Derivatives Using Asymmetric Hydrogenation Catalysts
This invention provides processes for the preparation of Sitagliptin and pharmaceutically acceptable salts thereof, said processes including enantioselective hydrogenation of a prochiral enamine using chiral ruthenium catalyst.
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| creator | HORNE STEPHEN E ABDUR-RASHID KAMALUDDIN CHEN XUANHUA GUO RONGWEI |
| description | This invention provides processes for the preparation of Sitagliptin and pharmaceutically acceptable salts thereof, said processes including enantioselective hydrogenation of a prochiral enamine using chiral ruthenium catalyst. |
| format | Patent |
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| subjects | APPARATUS THEREFOR CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY CHEMISTRY GENERAL METHODS OF ORGANIC CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY PERFORMING OPERATIONS PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL THEIR RELEVANT APPARATUS TRANSPORTING |
| title | Processes for the Preparation of Chiral Beta Amino Acid Derivatives Using Asymmetric Hydrogenation Catalysts |
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