Processes for the Preparation of Chiral Beta Amino Acid Derivatives Using Asymmetric Hydrogenation Catalysts

Processes for the Preparation of Chiral Beta Amino Acid Derivatives Using Asymmetric Hydrogenation Catalysts

This invention provides processes for the preparation of Sitagliptin and pharmaceutically acceptable salts thereof, said processes including enantioselective hydrogenation of a prochiral enamine using chiral ruthenium catalyst.

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Bibliographische Detailangaben
Hauptverfasser: HORNE STEPHEN E, ABDUR-RASHID KAMALUDDIN, CHEN XUANHUA, GUO RONGWEI
Format: Patent
Sprache:eng
Schlagworte:
APPARATUS THEREFOR
CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
PERFORMING OPERATIONS
PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
THEIR RELEVANT APPARATUS
TRANSPORTING
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Beschreibung
Zusammenfassung:This invention provides processes for the preparation of Sitagliptin and pharmaceutically acceptable salts thereof, said processes including enantioselective hydrogenation of a prochiral enamine using chiral ruthenium catalyst.