AMIDES AS PIM INHIBITORS

AMIDES AS PIM INHIBITORS

The invention relates to amide-containing compounds of formula (1), and salts thereof. In some embodiments, the invention relates to inhibitors or modulators of Pim-1 and/or Pim-2, and/or Pim-3 protein kinase activity or enzyme function. In still further embodiments, the invention relates to pharmac...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: CEE VICTOR, WU BIN, JACKSON CLAIRE L.M, TASKER ANDREW, SMITH ADRIAN L, WURZ RYAN, TAMAYO NURIA A, HARRINGTON ESSA HU, HERBERICH BRADLEY, CHEN JIAN J, LANMAN BRIAN A, CHAVEZ, JR. FRANK, PETTUS LIPING H, NORMAN MARK H, NGUYEN THOMAS T, REED ANTHONY B, WANG HUI-LING
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The invention relates to amide-containing compounds of formula (1), and salts thereof. In some embodiments, the invention relates to inhibitors or modulators of Pim-1 and/or Pim-2, and/or Pim-3 protein kinase activity or enzyme function. In still further embodiments, the invention relates to pharmaceutical compositions comprising compounds disclosed herein, and their use in the prevention and treatment of Pim kinase related conditions and diseases, preferably cancer.