Amine Derivatives as Potassium Channel Blockers

Amine Derivatives as Potassium Channel Blockers

The present invention relates to compounds useful in the modulation of potassium channel activity in cells, in particular the activity of Kv1.3 channels found in T cells. The invention also relates to the use of these compounds in the treatment or prevention of autoimmune and inflammatory diseases,...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: CROSSMAN JULIA, COLOVRAY VERONIQUE, JEANCLAUDE-ETTER ISABELLE, MOULD JORGEN, KUCHEL NATHAN, PAUL DHARAM, SINGH RAJINDER, AVERY THOMAS, DONINI CRISTINA, RIPPER JUSTIN, MOLETTE JEROME, HARVEY ANDREW, BOMBRUN AGNES, COOKE RACHEL
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The present invention relates to compounds useful in the modulation of potassium channel activity in cells, in particular the activity of Kv1.3 channels found in T cells. The invention also relates to the use of these compounds in the treatment or prevention of autoimmune and inflammatory diseases, including multiple sclerosis, pharmaceutical compositions containing these compounds and methods for their preparation.