GENE-GENE MODEL FOR ESTIMATING CANCER SUSCEPTIBILITY, RISK OF MULTIPLE TUMOR SITES, AND THE AGGRESSIVENESS OF PROSTATE CANCER

The present disclosure provides methods for estimating cancer susceptibility, risk of developing multiple tumor sites, and the aggressiveness of prostate cancer. Disclosed are interactions among three polymorphisms: the Acid Phosphatase Locus-1 (ACP1) 228C>T (rs11553742) and 413A>G (Q106R, rs7...

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1. Verfasser:	ANDAVOLU RADHIKA GADE
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PROCESSES OF PREPARING SUCH COMPOSITIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present disclosure provides methods for estimating cancer susceptibility, risk of developing multiple tumor sites, and the aggressiveness of prostate cancer. Disclosed are interactions among three polymorphisms: the Acid Phosphatase Locus-1 (ACP1) 228C>T (rs11553742) and 413A>G (Q106R, rs79716074) single nucleotide polymorphisms (SNPs), and a SNP for the Astrocyte Elevated Gene-1 (AEG1) (rs2438211). Additionally interactions among these polymorphisms are disclosed to modify the underlying quantitative expression of major cancer-related genes, indicating that optimization of these gene products by pharmacologic or gene therapy interventions would be beneficial as a cancer therapy to reduce the risk of tumor metastasis, and would also be beneficial in preventing cancer.