HUMAN ANTI-KIR ANTIBODIES

HUMAN ANTI-KIR ANTIBODIES

Compositions and methods for regulating an immune response in a subject are described. More particularly, described are human antibodies that regulate the activity of NK cells and allow a potentiation of NK cell cytotoxicity in mammalian subjects, and antibodies having antigen-binding properties sim...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: SVENDSEN IVAN, SVENSSON ANDERS, ROMAGNE FRANCOIS, KJAERGAARD KRISTIAN, ZAHN STEFAN, MORETTA ALESSANDRO, SPEE PIETER JOHANNES LOUIS, DELLA CHIESA MARIELLA, WAGTMANN PETER ANDREAS NICOLAI REUMERT, WILKEN MICHAEL, ANDRE PASCALE, THOROLFSSON MATTHIAS, GAUTHIER LAURENT, PADKAER SOREN BERG
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Compositions and methods for regulating an immune response in a subject are described. More particularly, described are human antibodies that regulate the activity of NK cells and allow a potentiation of NK cell cytotoxicity in mammalian subjects, and antibodies having antigen-binding properties similar to those of human monoclonal antibody 1-7F9 or 1-4F1. Described also are also fragments and derivatives of such antibodies, as well as pharmaceutical compositions comprising the same and their uses, particularly for use in therapy, to increase NK cell activity or cytotoxicity in subjects.