HETEROARYL COMPOUNDS USEFUL AS INHIBITORS OF E1 ACTIVATING ENZYMES

HETEROARYL COMPOUNDS USEFUL AS INHIBITORS OF E1 ACTIVATING ENZYMES

This invention relates to compounds that inhibit E1 activating enzymes, pharmaceutical compositions comprising the compounds, and methods of using the compounds. The compounds are useful for treating disorders, particularly cell proliferation disorders, including cancers, inflammatory and neurodegen...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: CLAIBORNE CHRISTOPHER F, CRITCHLEY STEPHEN, CULLIS COURTNEY, MIZUTANI HIROTAKE, VYSKOCIL STEPAN, WEATHERHEAD GABRIEL S, LANGSTON STEVEN P, OLHAVA EDWARD J, VISIERS IRACHE, PELUSO STEPHANE
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:This invention relates to compounds that inhibit E1 activating enzymes, pharmaceutical compositions comprising the compounds, and methods of using the compounds. The compounds are useful for treating disorders, particularly cell proliferation disorders, including cancers, inflammatory and neurodegenerative disorders; and inflammation associated with infection and cachexia.