SUBSTITUTED PYRIDINE SPLEEN TYROSINE KINASE (SYK) INHIBITORS

SUBSTITUTED PYRIDINE SPLEEN TYROSINE KINASE (SYK) INHIBITORS

The invention provides certain substituted pyridines of the Formula (I) or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, Rcy, Cy, and t are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds fo...

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Hauptverfasser: DONOFRIO ANTHONY, JEWELL JAMES P, ZHOU HUA, KNOWLES SANDRA LEE, SCHELL ADAM J, ALTMAN MICHAEL D, TAOKA BRANDON M, BURCH JASON, ROBICHAUD JOEL, DESCHENES DENIS, REUTERSHAN MICHAEL H, HAIDLE ANDREW M, ELLIS JOHN MICHAEL, CHRISTOPHER MATTHEW, BLOUIN MARC, FISCHER CHRISTIAN, NORTHRUP ALAN B, KATTAR SOLOMON D
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:The invention provides certain substituted pyridines of the Formula (I) or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, Rcy, Cy, and t are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions mediated by Spleen Tyrosine Kinase (Syk) kinase.