CORTISTATIN ANALOGUES AND SYNTHESES THEROF

CORTISTATIN ANALOGUES AND SYNTHESES THEROF

The present invention relates to analogs of cortistatin A, J, K, and L, having the general formula: I and salts thereof, wherein R1, R2, R3, R4, n, and m are as defined herein; processes for preparing such compounds and intermediates thereto; pharmaceutical compositions comprising such compounds; me...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: NIETO-OBERHUBER CRISTINA MONTSERRAT, SI CHONG, LEE HONG MYUNG, MYERS ANDREW G, SHAIR MATTHEW D, FLYER ALEC NATHANSON
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The present invention relates to analogs of cortistatin A, J, K, and L, having the general formula: I and salts thereof, wherein R1, R2, R3, R4, n, and m are as defined herein; processes for preparing such compounds and intermediates thereto; pharmaceutical compositions comprising such compounds; methods for treating a proliferative disease; methods for treating a disease associated with aberrant angiogenesis; methods for inhibiting angiogenesis; and processes for preparing cortistatin A, J, K, and L, and analogs thereof.