USEFUL COMBINATIONS OF MONOBACTAM ANTIBIOTICS WITH BETA-LACTAMASE INHIBITORS

USEFUL COMBINATIONS OF MONOBACTAM ANTIBIOTICS WITH BETA-LACTAMASE INHIBITORS

A pharmaceutical composition, comprising a combination of an antibiotically active compound of the formula (I): with a -lactamase inhibitor of one of the formulae (II) to (XIII) are active against Gram-negative bacteria, in particular such bacteria which have become resistant against antibiotics suc...

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Bibliographische Detailangaben
Hauptverfasser: ROUSSEL PATRICK, GAUCHER BÉRANGÈRE, PAGE MALCOM G.P, DESARBRE ERIC
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:A pharmaceutical composition, comprising a combination of an antibiotically active compound of the formula (I): with a -lactamase inhibitor of one of the formulae (II) to (XIII) are active against Gram-negative bacteria, in particular such bacteria which have become resistant against antibiotics such as aztreonam, carumonam and tigemonam. Optionally the compositions may comprise another -lactamase inhibitor of one of the formulae (II) to (XIII), particularly of formula (V) or formula (VI).