Compounds And Methods For Selective Imaging And/Or Ablation

The invention relates generally to compounds and methods for imaging and/or selective ablation of nitroreductase-expressing cells and/or biological agents. More particularly, although not exclusively, the invention provides compounds that are selectively metabolised by bacterial nitroreductases and...

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Bibliographische Detailangaben
Hauptverfasser:	ANDERSON ROBERT FORBES, ASHOORZADEH AMIR, WILLIAMS ELSIE MAY, COPP JANINE NAOMI, MOWDAY ALEXANDRA MARIE, KOCH CAMERON, PATTERSON ADAM VORN, DOLBIER, JR. WILLIAM R, GUISE CHRISTOPHER PAUL, SMAILL JEFFERY BRUCE, KACHUR ALEX, ACKERLEY DAVID FRANCIS
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY DIAGNOSIS HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE IDENTIFICATION MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SURGERY
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Beschreibung
Zusammenfassung:	The invention relates generally to compounds and methods for imaging and/or selective ablation of nitroreductase-expressing cells and/or biological agents. More particularly, although not exclusively, the invention provides compounds that are selectively metabolised by bacterial nitroreductases and are substantially insensitive to metabolism under oxic or hypoxic conditions by human nitroreductase enzymes.