RHO KINASE INHIBITORS

RHO KINASE INHIBITORS

Disclosed are novel substituted 2H-isoquinolin-1-one and 3H-quinazolin-4-one derivatives useful as inhibitors of Rho kinase and for treating a variety of diseases and disorders that are mediated or sustained through the activity of Rho kinase, including cardiovascular diseases, pharmaceutical compos...

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Bibliographische Detailangaben
Hauptverfasser: WU FRANK, HICKEY EUGENE RICHARD, PROKOPOWICZ ANTHONY S, SHIH CHENG-KON, BOSANAC TODD, YOUNG ERICK RICHARD, KIRRANE, JR. THOMAS MARTIN, GINN JOHN DAVID, LIU WEIMIN, SCHLYER SABINE K, SNOW ROGER JOHN, TURNER MICHAEL ROBERT
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:Disclosed are novel substituted 2H-isoquinolin-1-one and 3H-quinazolin-4-one derivatives useful as inhibitors of Rho kinase and for treating a variety of diseases and disorders that are mediated or sustained through the activity of Rho kinase, including cardiovascular diseases, pharmaceutical compositions comprising such compounds, methods for using such compounds and processes for making such compounds.