INHIBITORS OF ARGINASE AND THEIR THERAPEUTIC APPLICATIONS

INHIBITORS OF ARGINASE AND THEIR THERAPEUTIC APPLICATIONS

The inventive compounds are small molecule therapeutics that are potent inhibitors of Arginase I and II activity. The invention also provides pharmaceutical compositions of the inventive compounds and methods for using the inventive compounds for treating or preventing a disease or a condition assoc...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: GOLEBIOWSKI ADAM, WHITEHOUSE DARREN, RYDER TODD, BECKETT RAYMOND PAUL, JI MIN KOO, VAN ZANDT MICHAEL
Format: Patent
Sprache:eng
Schlagworte:
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The inventive compounds are small molecule therapeutics that are potent inhibitors of Arginase I and II activity. The invention also provides pharmaceutical compositions of the inventive compounds and methods for using the inventive compounds for treating or preventing a disease or a condition associated with arginase activity.