Process and Intermediate Compounds Useful in the Preparation of Statins, Particularly Rosuvastatin

Process and Intermediate Compounds Useful in the Preparation of Statins, Particularly Rosuvastatin

Provided are a compound of formula (5) and a process for its preparation wherein: R1 represents an alkyl group; R2 represents an aryl group; R3 represents a protecting group or an alkyl group; R4 represents a protecting group or a SO2R5 group where R5 is an alkyl group; R6 represents (PR7R8)+X− or P...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: MOODY DAVID J, WIFFEN JONATHAN W
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:Provided are a compound of formula (5) and a process for its preparation wherein: R1 represents an alkyl group; R2 represents an aryl group; R3 represents a protecting group or an alkyl group; R4 represents a protecting group or a SO2R5 group where R5 is an alkyl group; R6 represents (PR7R8)+X− or P( O)R7R8 in which X is an anion and R7 and R8 each independently is an alkyl, aryl, alkoxy, or aryloxy group; P1 represents hydrogen or a protecting group; and W represents O or OP2, in which P2 represents hydrogen or a protecting group.