HYPOALLERGENIC CHIMERIC PROTEINS BELONGING TO THE LIPID TRANSFER FAMILY OF PARIETARIA JUDAICA FOR USE IN THE TREATMENT OF ALLERGIES

HYPOALLERGENIC CHIMERIC PROTEINS BELONGING TO THE LIPID TRANSFER FAMILY OF PARIETARIA JUDAICA FOR USE IN THE TREATMENT OF ALLERGIES

The present invention relates to recombinant DNA molecules which encode chimeric polypeptides of differing allergens of Parietaria judaica which can be used for the prevention and treatment of allergies, in particular pollen allergies. Specifically, chimeric polypeptides composed of fragments of the...

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Bibliographische Detailangaben
Hauptverfasser: GARATE ALBERTO MARTINEZ, RIOJA ROBERTO GONZALES, ASTURIAS JUAN ANDRES
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:The present invention relates to recombinant DNA molecules which encode chimeric polypeptides of differing allergens of Parietaria judaica which can be used for the prevention and treatment of allergies, in particular pollen allergies. Specifically, chimeric polypeptides composed of fragments of the allergens Par j 1 and Par j 2 having hypoallergenic characteristics are described. Methods for producing these recombinant polypeptides in heterologous expression systems are also described. Efficient methods of purifying the chimeric proteins are also described.