OXIDATION AND AMINATION OF PRIMARY ALCOHOLS

The present invention relates to a method comprising the steps a) providing a primary alcohol of the formula HO-(CH2)x-R1, wherein R1 is selected from the group consisting of -OH, -SH, -NH2 and -COOR2, x is at least 3 and R2 is selected from the group consisting of H, alkyl and aryl, b) oxidizing th...

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Bibliographische Detailangaben
Hauptverfasser:	PÖTTER MARKUS, PFEFFER JAN CHRISTOPH, LERCHNER ALEXANDRA, SCHAFFER STEFFEN, HAAS THOMAS, SKERRA ARNE, SATTLER JOHANN H, TAUBER KATHARINA CHRISTIN, KROUTIL WOLFGANG
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION ORPROCESSING OF GOODS ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING SPIRITS TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINSTCLIMATE CHANGE VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention relates to a method comprising the steps a) providing a primary alcohol of the formula HO-(CH2)x-R1, wherein R1 is selected from the group consisting of -OH, -SH, -NH2 and -COOR2, x is at least 3 and R2 is selected from the group consisting of H, alkyl and aryl, b) oxidizing the primary alcohol by contacting it with an NAD(P)+-dependent alcohol dehydrogenase, and c) contacting the oxidation product of step a) with a transaminase, wherein the NAD(P)+-alcohol dehydrogenase and/or the transaminase is a recombinant or isolated enzyme, to a whole cell catalyst for carrying out the method, and to the use of such a whole cell catalyst for oxidizing a primary alcohol.