MODULAR POLYMER HYDROGEL NANOPARTICLES AND METHODS OF THEIR MANUFACTURE

In certain embodiments, a nano-sized vehicle (e.g., a nanogel comprising nanoparticles) is provided herein for drug delivery with tunable biodistribution, low toxicity, and degradability, and with demonstrated targeting to bone. The composition is useful, for example, in the treatment of bone diseas...

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Bibliographische Detailangaben
Hauptverfasser: ANDERSON DANIEL G, LEVI YAIR, HELLER DANIEL A, LANGER ROBERT, PRATT GEORGE W, WALLAS JASMINE
Format: Patent
Sprache:eng
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Zusammenfassung:In certain embodiments, a nano-sized vehicle (e.g., a nanogel comprising nanoparticles) is provided herein for drug delivery with tunable biodistribution, low toxicity, and degradability, and with demonstrated targeting to bone. The composition is useful, for example, in the treatment of bone disease, particularly bone metastases from cancers such as breast, prostate, or lung cancer.