NOVEL CRYSTALLINE FORM OF ATORVASTATIN HEMI-CALCIUM SALT, HYDRATE THEREOF, AND METHOD OF PRODUCING THE SAME

NOVEL CRYSTALLINE FORM OF ATORVASTATIN HEMI-CALCIUM SALT, HYDRATE THEREOF, AND METHOD OF PRODUCING THE SAME

The present invention provides a novel crystalline form of [R-(R*,R*)]-2-(4-fluorophenyl)- ,δ-dihydroxy-5-(1-mthylethyl)-3 -phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-heptanoic acid hemi-calcium salt (atorvastatin hemi-calcium salt) of the following formula 1, which is known to be useful as a drug...

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Bibliographische Detailangaben
Hauptverfasser: CHANG SUN HO, OH DO YEON, LEE KYUNG JU, CHOI DOO SEONG, SON HOE JOO
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The present invention provides a novel crystalline form of [R-(R*,R*)]-2-(4-fluorophenyl)- ,δ-dihydroxy-5-(1-mthylethyl)-3 -phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-heptanoic acid hemi-calcium salt (atorvastatin hemi-calcium salt) of the following formula 1, which is known to be useful as a drug, a hydrate thereof and a preparation method thereof: