AMINOMETHYL BIARYL BENZOTRIAZOLE DERIVATIVES

The present invention is directed to aminomethyl biaryl benzotriazole derivatives which are potentiators of metabotropic glutamate receptors, particularly the mGluR2 receptor, and which are useful in the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysf...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: JOHNSON ADAM W, BESHORE DOUGLAS C, GARBACCIO ROBERT M, KUDUK SCOTT D, SKUDLAREK JASON W
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:The present invention is directed to aminomethyl biaryl benzotriazole derivatives which are potentiators of metabotropic glutamate receptors, particularly the mGluR2 receptor, and which are useful in the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which metabotropic glutamate receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which metabotropic glutamate receptors are involved.