Genetically Modified Microorganisms Capable of Producing Beta-Glucans and Methods for Producing Beta-Glucans

The present invention relates to genetically modified microorganisms capable of producing beta-glucans, characterized in that said genetically modified microorganism overexpresses (i) a polynucleotide encoding a polypeptide having 1,3-beta-D-glucan synthase-activity, and/or (ii) a polypeptide having...

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Hauptverfasser: BROCKMANN BEATA, SCHMIDT JULIA KRISTIANE, FLECK CHRISTIAN, GRANSTROEM MARI, ZELDER OSKAR, HEROLD ANDREA, HAEFNER STEFAN, SCHROEDER HARTWIG
Format: Patent
Sprache:eng
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Zusammenfassung:The present invention relates to genetically modified microorganisms capable of producing beta-glucans, characterized in that said genetically modified microorganism overexpresses (i) a polynucleotide encoding a polypeptide having 1,3-beta-D-glucan synthase-activity, and/or (ii) a polypeptide having 1,3-beta-D-glucan synthase-activity, compared to a corresponding non-modified control microorganism of the same strain. The present invention also relates to the use of a polynucleotide encoding a polypeptide having 1,3-beta-D-glucan synthase-activity or the use of such a polypeptide for producing beta-glucans. Furthermore, the present invention relates to methods for producing beta-glucans comprising the introduction of a promoter upstream of a polynucleotide encoding a polypeptide having 1,3-beta-D-glucan synthase-activity thereby increasing the expression of said polynucleotide, or a polynucleotide encoding a polypeptide having 1,3-beta-D-glucan synthase-activity into a microorganism being able to synthesize beta-glucans.