DERIVATIVES OF SMALL INTERFERING RNAS AND USE THEREOF

The present invention relates to a small interfering RNA (siRNA) being 2'-O-methyl modified and there being attached thereto by a phosphodiester bond a position 3', wherein group R in position 3', wherein R is selected from among: a C1-C6 alkyl substituted with at least one -OH group;...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	FERNANDEZ GIMENO ESTER, ERITJA CASADELLA RAMON, ROMERO PRADA CAROLINA, PERALES JOSE CARLOS, BURGUENO BANUS JUAN, OCAMPO SANDRA MILENA
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention relates to a small interfering RNA (siRNA) being 2'-O-methyl modified and there being attached thereto by a phosphodiester bond a position 3', wherein group R in position 3', wherein R is selected from among: a C1-C6 alkyl substituted with at least one -OH group; a C4-C6 cycloalkyl substituted with at least one -OH group; a C4-C6 heterocycloalkyl; a heteroalkyl chain having between 2 and 7 atoms, wherein at least one is an oxygen atom or a sulphur atom, the chain preferably being substituted with at least one -OH group; and a heteroaryl the ring whereof being formed of between 3 and 6 atoms and at least one of said atoms is an oxygen atom. The present invention furthermore refers to the use of said siRNA for the treatment of inflammatory diseases, preferably inflammatory bowel disease.